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May 2007

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Cover Story
Conquering the Almighty Cell
Scientists have long known that the toughest confrontation with cells occurs in a one-on-one basis. But as technologies improve, it has become possible to interrogate individual cells for a number of applications, from RNAi to proteomics and more.

Feature Story
Neuroscience: The New Array Frontier
Researchers put expression analysis through its paces to parse out neurological diseases

What’s Beyond Comparison? Function
Comparative genomics is evolving beyond its computational roots as scientists attempt to elucidate function for genomic regions of interest

Markers
TIGR’s Fraser-Liggett to Start New Institute at Maryland
LEADERSHIP

UCLA Team Spits Out First Look at Salivary Proteome
PROTEOMICS

As Genomics Companies Rush to IPO, Some Worry It’s Bad News
IPOs

$100M Gift to Broad Starts New Psych Research Center
PSYCHIATRIC DISEASE

Genstruct Appoints Reich as New Research VP
SYSTEMS BIOLOGY

BC's Holt Pushes Ahead With Synthetic Bio
MICROBIAL GENOMICS

With Repository Overload, Researchers Try New Ways to Integrate
DATABASES

Short Reads
NEWS IN BRIEF

Careers
Mastering Business
Is it worth the time and money to get your MBA to pursue a path beyond the bench?

Under One Roof
Michigan’s Scientific Mash-Up
The Life Sciences Institute is an ongoing experiment in what happens when you mix science, scientists, and even (horrors!) lab space.

Informatics Insider
Of Trolls and Tubes
A columnist takes a Proustian stroll through proteomic informatics, wondering just how many elves it takes to clog a pipeline

Brute Force
Smith-Waterman's New Clothes
Still devoted to Blast? What if Smith-Waterman was quicker? A zippy new software implementation of the classic search tool offers an alternative to hardware acceleration.

Pattern Recognition
Dollars for Disease
GRANTS, BUDGETS & FUNDING DATA

Technology Spotlight
Changing Tune, Dx Providers Offer Prenatal CGH Tests
MICROARRAYS

Biobase to Build In Silico Drug Development Toolbox
BIOINFORMATICS

Purification, Standards Challenge Protein Expression
PROTEOMICS

Roche and 454: Could’ve Stayed Friends
SEQUENCING

Calando Demos Safe siRNA Delivery in Primates
RNA INTERFERENCE

In the Clinic
From Lab to Clinic: Taming Diabetes
CASE STUDY

Spanning Science and Clinic
Q&A

IoM: FDA, Industry Accord Aids Dx-Rx Co-Development
NEWS SPOTLIGHT

Calendar & Deadlines
Upcoming Events
MEETINGS, DEADLINES & WORKSHOPS

Where Are They Now
PGx in the Recent and Distant Past, Next-Gen Sequencers, and Nanotech
GT IN YEARS PAST

Primer
The Value of One
LETTER FROM THE EDITOR

Blunt End
Pop Quiz! It’s the Year in Review
THE HUMOR PAGE

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